Rotor-stator systems for particle size reduction (0.1-50μm). Applications:
Nanoemulsions (cosmeceuticals)
Cell lysates (biopharma)
Pigment dispersion (paints)
Features: 1-100kW power, CIP/SIP, explosion-proof options
Jacketed vessels with temperature control (-25°C to +350°C):
Glass-lined: Acid/halogen resistance (chemical synthesis)
316L SS: Pharma-grade (API intermediates)
Pressure-rated: Hydrogenation (up to 100 bar)
Capacity: 50-10,000L
Hybrid units combining:
Vacuum drying + mixing
Emulsification + heating/cooling
Powder-liquid dispersion + deaeration
Ideal for OTC drugs, adhesives, battery slurries
| Parameter | Laboratory | Pilot Scale | Production |
|---|---|---|---|
| Capacity | 0.5-50 L | 50-500 L | 500-10,000 L |
| Shear Rate | Up to 25,000 rpm | Up to 15,000 rpm | Up to 3,000 rpm |
| Temp Control | ±1°C | ±2°C | ±5°C |
| Pressure Range | Atmospheric | 0-10 bar | 0-100 bar |
| Sector | Key Processes | Critical Features |
|---|---|---|
| Pharma | Vaccine adjuvants, lipid nanoparticles | GMP, CIP/SIP, 316L SS |
| Chemicals | Polymerization, catalyst recovery | ATEX, Hastelloy lining |
| Cosmetics | Silicone emulsions, sunscreen formulations | Non-foaming design, shear control |
| Food | Nutraceutical suspensions, flavor blends | EHEDG, food-grade seals |
Energy Efficiency: 45% lower power vs. conventional agitators (optimized impeller design)
Scale-Up Accuracy: Consistent results from R&D → production (Re number matching)
Smart Control:
PAT integration (Raman/NIR sensors)
Viscosity feedback loops
Recipe management (21 CFR Part 11)
Material Versatility:
Ceramic-coated shafts for abrasives
PTFE seals for solvents
| Requirement | Implementation |
|---|---|
| Cleanability | Ra ≤0.4 μm surface finish, dead-leg-free piping |
| Explosion Safety | Pressurized enclosures, nitrogen inerting ports |
| Traceability | Material certificates (3.1/3.2), weld mapping |
| Validation | IQ/OQ/PQ packages, FAT/SAT protocols |
| Market | Standards | Documentation |
|---|---|---|
| EU | PED 2014/68/EU, ATEX 2014/34/EU | CE Technical File |
| USA | ASME BPE, FDA 21 CFR 211 | URS/FAT protocols |
| China | GB150, ASME with China Mark | MLA (Manufacturer License) |
| SE Asia | GMP PIC/S, ISO 80079 | Local agent validation support |
Heating/Cooling: Electric, steam, or thermal oil
Vacuum Systems: Down to 0.1 mbar (deaeration)
Automation:
Siemens PCS7 PLC
DeltaV integration
Remote monitoring via IIoT
Safety:
Rupture discs
Emergency quenching
Ex-proof motor options
Engineered for demanding applications:
Pharma: ≤0.1 μm emulsion stability (liposomes, mRNA vaccines)
Chemicals: Corrosion-resistant reactors for HCl/HF processing
Cosmetics: Shear-sensitive silicone emulsification
Scale Flexibility: Identical geometry from 5L → 5,000L
Request application-specific engineering:
Nanoparticle Synthesis: Shear-controlled crystallization
Hazardous Chemistry: ATEX-certified pressure reactors
Cleaning Validation: Swab test reports for GMP
🌐 Request Compliance Audit: Free gap analysis with throughput simulation.
✅ GMP Compliance Guarantee
✅ 24/7 Multilingual Support
✅ 24-month performance guarantee
✅ Local technicians in 18 countries
Free line configuration for your products, throughput validation testing!
Contact Specialists for Packaging Equipment:
Compliance Roadmap:
