Advanced Strip-Monodose Ampoule Packaging Machine
GMP-plastic-ampoule-rotary-monobloc.
Automated-FFS-line-film-to-finished-product.
LOCUS GROUP designs and delivers integrated strip-monodose solutions for pharmaceuticals, nutraceuticals, and cosmetics. As demand surges for unit-dose packaging in Russia and globally, our systems enable brands to launch competitively packaged products with minimal investment.
LOCUS PHARM delivers GMP-compliant strip-monodose solutions for unit-dose pharmaceuticals, nutraceuticals, and diagnostic liquids. Our plastic ampoule systems combine precision filling with hermetic sealing for oxygen-sensitive products like vaccines, ophthalmics, and injectables.
| Machine | Function | Throughput | Key Features |
|---|---|---|---|
| ALSM-100T | Peristaltic dosing | 500-800 units/hr | • ±1% accuracy • Nitrogen purging option • Quick-change cassettes |
| ALSM-100G | Ultrasonic welding | 600-900 units/hr | • 20-40kHz frequency control • Burst pressure ≥35 psi • Benchtop footprint |
| Machine | Function | Throughput | Key Features |
|---|---|---|---|
| ALSM-50 | Peristaltic dosing | 500-800 units/hr | • ±1% accuracy • Quick-change tooling • Nitrogen purging option |
| ALSM-50M | Ultrasonic welding | 600-1,000 units/hr | • Frequency-stabilized (20kHz) • Energy director optimization • Burst pressure testing |
| Machine | Configuration | Throughput | GMP Features |
|---|---|---|---|
| ALSM-50L | Carousel fill/seal | 1,500-2,500 u/hr | • AISI 316L contact surfaces • CIP capability • Data logging (21 CFR Part 11) |
| ALSM-100M | Full automation (fill/seal/label/mark) | 5,000-8,000 u/hr | • Vision inspection • Track-and-trace integration • Isolator compatibility |
| Model | Operation | Output | GMP Features |
|---|---|---|---|
| ALSM-50 | 4-pocket rotary indexing | 1,200-2,000 u/hr | • Auto fill/seal cycle • Touchscreen HMI • Data logging |
| ALSM-50R | 6-pocket carousel | 2,500-3,500 u/hr | • CIP capability • AISI 304 contact surfaces • O₂ monitoring |
| Parameter | Specification |
|---|---|
| Ampoule Materials | LDPE ∙ COC ∙ Cyclic Olefin Copolymers (Barrier properties: OTR <0.5 cc/pkg/day) |
| Fill Volume | 0.5ml — 10ml (±1% accuracy with servo piston) |
| Sealing Integrity | Burst pressure ≥35 psi (ASTM F1140) |
| Oxygen Protection | Nitrogen purging ≤50 ppm residual O₂ |
| Compliance | FDA 21 CFR Part 211 ∙ EU Annex 1 ∙ ISO 15378 |
Workflow:
| Model | Technology | Output | Advantages |
|---|---|---|---|
| ALSM-100 | Vertical FFS from film reels | 5,000-8,000 u/hr | • 30% material cost savings • Integrated vision inspection • Labeling module |
| ALSM-100K | Horizontal continuous motion | 10,000-15,000 u/hr | • Changeover <15 min • ≤0.2% material waste • Track-and-trace integration |
Material Traceability: Documentation per ICH Q7
Cleanability: Electropolished surfaces (Ra ≤0.5 µm)
Change Control: Tool-less format adjustment
Validation: IQ/OQ protocols for:
Fill weight verification
Seal strength testing
Container closure integrity
| Type | Best For | Accuracy | LOCUS Implementation |
|---|---|---|---|
| Peristaltic | Shear-sensitive liquids | ±1% | Glass check valves ∙ 3/6-roller heads |
| Gear Pump | High-viscosity products | ±0.5% | CIP-ready ∙ PTFE gears |
| Servo Piston | Oils & suspensions | ±0.3% | Anti-drip nozzles ∙ Recipe management |
Growing Demand Drivers:
45% YOY growth in nutraceutical unit-dose packaging
30% cost reduction vs. glass ampoules
Enhanced portability for sports/beauty products
+ 35% faster sealing vs. thermal methods
+ Oxygen-sensitive protection: <0.3% product oxidation
+ Reduced material waste: 70% less vs. glass ampoules
- No glass breakage risk
Competitive Edge:
+ 45% lower entry cost vs. European systems
+ 15 min format changeover
+ Local technical support
- No minimum order quantity
Precision Engineering:
Our servo-piston fillers achieve ±0.5% accuracy with viscous biologics — critical for monoclonal antibody unit-dosing.
Sealing Integrity:
Frequency-controlled ultrasonic horns ensure consistent weld depth (±3µm) — eliminating leakers in accelerated stability trials.
Cost Efficiency:
Reduce packaging costs by 35% versus vials while maintaining equivalent barrier properties with COC materials.
| Phase | Deliverables |
|---|---|
| IQ | • Installation verification • Calibration records • Material certificates |
| OQ | • Fill weight uniformity (USP <905>) • Seal strength validation • CIP efficacy |
| PQ | • 3-batch consistency • Container closure integrity • Particulate monitoring |
| Market | Configuration | Special Features |
|---|---|---|
| Russia/CIS | Standard voltage (220V) | • Russian/English interfaces • GOST-R certification |
| Global Export | Multi-voltage (110V-200V-380V-480V) | • CE/UKCA markings • Multi-language documentation |
| Market | Configuration Package |
|---|---|
| Southeast Asia | Tropical: Dehumidified control cabinets + salt-spray certified components |
| Africa | Power-stable: 90V-100V-220V-380V-480V input + surge protection |
| Middle East | Dust-proof: IP65 rating + positive pressure HMI |
| Latin America | Multi-language: Spanish/Portuguese interfaces |
Cost Efficiency:
Launch new product lines with our ALSM-50 monobloc at 55% lower investment than automated systems — ROI in 4 months at 2,500 units/day.
Quality Assurance:
Frequency-stabilized ultrasonic sealing ensures consistent weld integrity — ≤0.03% leaker rate in accelerated stability tests.
Material Savings:
ALSM-100 lines reduce packaging costs by 35% using raw film instead of pre-formed strips — ideal for high-volume SKUs.
| Parameter | LOCUS ALSM-100 | Industry Average |
|---|---|---|
| Output | 3,500 units/hr | 2,000 units/hr |
| Changeover Time | 10 min | 30 min |
| Energy Consumption | 1.8 kW | 3.5 kW |
| Footprint | 0.8m² | 1.5m² |
| Parameter | LOCUS ALSM-100B | Industry Standard |
|---|---|---|
| Output | 8,000 units/hr | 5,000 units/hr |
| Format Changeover | 15 min (tool-less) | 60 min |
| O₂ Ingress | <0.1% over 24 months | <0.5% |
| Material Waste | 3% | 8-12% |
Semi-Automatic Workstations, Rotary Monobloc Solutions, Fully Automated Lines.
Semi-Automatic Workstations, Rotary Monobloc Solutions, Automated FFS Lines.
Ultrasonic-sealing-process-closeup.
Rotary-monobloc-strip-monodose-production.
✅ GMP Compliance Guarantee
✅ 24/7 Multilingual Support
✅ 24-month performance guarantee
✅ Local technicians in 18 countries
Free line configuration for your products, throughput validation testing!
Contact Specialists for GMP:
Compliance Roadmap:
CE, EAC, ISO 9001 certifications.
GMP-ready: 316L SS contact parts, CIP/SIP capabilities.
