GMP-Certified Reactors & Process Vessels: Precision Engineered to Your URS
GMP Reactors for Pharma | CIP/SIP Systems.
Cosmetic Manufacturing Tanks | High-Shear Homogenizers.
Food-Grade Processing Vessels | Carbonation & CIP Systems.
500L GMP bioreactor electropolished 316L SS ASME BPE.
Conical bottom reactor high shear homogenizer cosmetic.
LOCUS GROUP manufactures custom reactors and process vessels for critical applications in pharmaceuticals, cosmetics, cemicals and food production. Engineered to your User Requirement Specifications (URS), our solutions. Also We delivers bespoke reactor and tank systems, from design to commissioning, we provide turnkey solutions.
Core Technical Specifications:
Materials: AISI 304L, 316L, or 12X18H10T stainless steel (Ra ≤0.38µm electropolished finish)
Capacity: 10L R&D → 10,000L production scale
Compliance: EU GMP Annex 1, HACCP, ATEX, FDA 21 CFR 211
Surface Finish: Ra ≤0.4μm (pharma), Ra ≤0.8μm (industrial)
Pressure Rating: Up to 12 bar (custom to 20 bar)
Geometry: Conical or elliptical bottoms (ASME BPE compliant)
| Industry | Key Equipment Types | Technical Highlights |
|---|---|---|
| Cosmetics | Emulsion tanks, homogenizers | 15,000 RPM high-shear heads, heating mantles |
| Pharma | GMP reactors (OEB 4/5) | Passivated 316L, CIP/SIP, 3D weld mapping |
| Food & Beverage | Syrup cookers, fermentation vessels | EHEDG design, glycol jacketing |
| Industrial Chem | ATEX-rated reactors, plastic/glass liners | Explosion-proof controls, fume extraction |
Essential Systems
Technical Components:
Agitation: Propeller, anchor, planetary mixers (up to 2,000 rpm)
Heating: Electric (350°C), steam (10 bar), thermal oil (-30°C to +300°C)
Automation: Recipe-based control with 21 CFR Part 11 compliance
Safety: ASME pressure relief valves, rupture discs
Monitoring: PT100 sensors, radar level transmitters
| Chemical Type | Recommended Material | Critical Features |
|---|---|---|
| Acids/Alkalis | Hastelloy®/PP-lined reactors | 5mm corrosion allowance |
| Chlorine Compounds | Glass reactors | 0% metal contact |
| Pharma APIs | 316L EP (Ra≤0.38µm) | Full material traceability |
| Food Products | 304L with #4 finish | EHEDG-certified welds |
Complete Line Examples:
Cosmetics Line:
Reactor → Homogenizer → Filtration → Filling Machine
Pharma Line:
GMP Reactor → CIP → Buffer Tank → Vial Filler
Chemical Line:
ATEX Reactor → Fume Hood → Drum Filler
GMP syrup cooker fermentation vessels → Homogenizer → Filtration → Filling Machine
| Feature | Pharma Specification | Industrial Specification |
|---|---|---|
| Viewing Ports | 100mm borosilicate glass | 150mm tempered glass |
| Connections | Tri-clamp (ASME BPE) | DIN 11851/RJT |
| Agitation | Magnetic drive (0-500 rpm) | Shaft-mounted (0-2000 rpm) |
| Heating/Cooling | Dual-circuit jacket | Single-circuit thermal oil |
| Surface Finish | Ra ≤0.38µm (EP) | Ra ≤0.8µm (Mechanical polish) |
| Documentation | Full IQ/OQ/PQ validation | Material certificates |
Tropicalized Designs for SEA/Africa:
316L SS with 2.0% Mo content for salt resistance
IP66-rated electrical panels
External insulation with climatic guard
Middle East Chemical Plants:
Sand-blasted exteriors (anti-glare)
Air-cooled heat exchangers
Pharma-Grade Validation:
All vessels include full material traceability (EN 10204 3.1), passivation reports per ASTM A967, and surface roughness maps — exceeding. Also All GMP vessels include EN 10204 3.2 certificates, ASTM E290 bend test reports, and electropolishing validation PIC/S PE 009-14 requirements.
Advanced Agitation:
Triple-motion planetary mixers achieve 98.4% homogeneity in high-viscosity creams (up to 500,000 cP) with <0.3% aeration.
Tropicalized Designs:
Southeast Asia models feature 316L SS (2.0% Mo content) for salt resistance, external insulation jackets, and IP66-rated control panels for high-humidity environments.
URS-Driven Precision: Every vessel built to your exact technical specifications
Cross-Industry Expertise: Pharma-grade to ATEX-certified designs
Seamless Integration: Pair reactors with our filling/packaging lines
Tropical Resilience: 316L Mo-enhanced steel for humid climates
Certifications Highlight:
Pharma: GMP, FDA 21 CFR 211
Food: HACCP, 3-A Sanitary
Industrial: ATEX, PED 2014/68/EU
Request Your Custom Reactor Solution!
Start Your Custom Reactor Project!
Engineer Your Precision Processing Vessel (Reactor)!
✅ GMP Compliance Guarantee
✅ 24/7 Multilingual Support
✅ 24-month performance guarantee
✅ Local technicians in 18 countries
Free line configuration for your products, throughput validation testing!
Contact Specialists for GMP:
Compliance Roadmap:
CE, EAC, ISO 9001 certifications.
GMP-ready: 316L SS contact parts, CIP/SIP capabilities.
