Description
Integrated Aseptic Processing for Critical Injectables
In sterile pharmaceutical manufacturing, reducing intervention is paramount. This LR-200 monoblock integrates filling, stoppering, and crimping into a single, compact rotary platform, minimizing exposure and handling risk. The process is designed to maintain the sterility of the product path from the filling nozzles through to the sealed vial, providing a robust solution for infusion solutions, parenteral nutrition, blood volume substitutes, and other sterile injectables.
Key Features & Operational Benefits
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Complete Vial Closure System: Executes the full Fill-Stopper-Crimp sequence in one machine: precision dosing, placement of lyophilization or infusion stoppers, and final aluminum seal crimping.
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Aseptic & GMP-Ready Design: All product contact parts are AISI 316L Stainless Steel, electropolished. The design is compatible with Clean-in-Place and Sterilize-in-Place (CIP/SIP) procedures and is constructed to support validation for EU GMP Annex 1 and similar standards.
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High-Precision, Four-Piston Filling: Four independent, volumetrically controlled piston cylinders ensure accurate fill-volume control for large-volume parenterals, with minimal product loss or shear stress.
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Specialized Tooling for Pharma Closures: Equipped with a stopper insertion head for siliconeized rubber stoppers and a three-roller crimping head to apply tamper-evident aluminum flip-off caps securely and consistently.
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Dedicated Component Handling: Features two vibratory orienters to correctly align and feed rubber stoppers and aluminum caps to the respective application heads.
Technical Specifications: LR-200 Aseptic Monoblock
| Feature | Specification |
|---|---|
| Machine Type | Rotary (Carousel) Aseptic Monoblock Filler, Stoppering & Crimping Machine |
| Filling Technology | Volumetric Piston Dosing (4 cylinders) |
| Piston Material | AISI 316L Stainless Steel |
| Primary Container | BCZ (Blood Container, Glass) Vials |
| Vial Volumes | 50 ml, 100 ml, 250 ml, 450 ml |
| Closure System | Silicone-Coated Rubber Stoppers + Aluminum Flip-Off Caps |
| Cap Sizes (Crimping) | Flip-Off Caps K2-28, K3-32, K3-34 |
| Component Handling | 2 x Vibratory Orientes (for Stoppers & Caps) |
| Primary Applications | Infusion Solutions, Blood Substitutes (Plasma Expanders), Sterile Injectables, LVPs |
| Compliance (Standard) | GMP-ready (Annex 1), CIP/SIP-capable, CE/EAC, ISO 9001 |
Global Support for Pharmaceutical Manufacturers
This machine is supported by a framework designed for validated, critical processes:
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Full Validation Support: Comprehensive documentation and remote assistance for Installation, Operational, and Performance Qualification (IQ/OQ/PQ) protocols is included.
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Pharma-Focused Service: Specialized technical support from our global hubs, with an understanding of sterile process requirements and audit trails.
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Guaranteed System Performance: Backed by a 24-month performance guarantee and expert line configuration to ensure your aseptic process is optimized from the start.
📜 Schedule virtual airflow visualization test.
💡 Mention your: Target market (EU/US/Global South), Active ingredient, Required throughput.
🔬 Schedule virtual factory acceptance test with our engineers.
🏷️ Request Compliance Audit: Free gap analysis with throughput simulation.
🔍Ready to Eliminate Production Bottlenecks?
💎Need Industrial Production Automation?
✅ GMP Compliance Guarantee
✅ 24/7 Multilingual Support
✅ 24-month performance guarantee
✅ Local technicians in 18 countries
📈Start small, get a free production layout designed for your growth trajectory. Scale smarter with engineering support!
📥Free line configuration for your products, throughput validation testing!
🎓Contact Specialists for Packaging Equipment:
📄 On-Demand Engineering: Product-specific configurations in 1-2 weeks.
🔧 Spare Parts Kits: Region-specific inventory for <24hr delivery.
🧼Compliance Roadmap:
- CE, EAC, ISO 9001 certifications.
- GMP-ready: 316L SS contact parts, CIP/SIP capabilities.
- ATEX options for chemical solvents.
